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Docetaxel(Taxotere),a semisynthetic analogue of the antitumor agent paclitaxel,inhibits tubulin depolymerization,Paclitaxel produces a peripheral neuropathy.This study delineates clinically and electrophysiologically the characteristics of a peripheral neuropathy due to docetaxel.In 186 patients receiving docetaxel in phase I or phase II protocols,we performed serial neurologic exams.As patients became symptomatic,quantitative sensory testing and nerve conduction studies were done.Twenty-one patients developed mild to moderate sensory neuropathy on taxotere at a wide range of cumulative doses(50 to 750 mg/m2)and dose levels(10 to 115 mg/m2).Ten of these patients also developed weakness of varying degree in proximal and distal extremities.Nine of the 21 patients had received neurotoxic chemotherapy before;16 were treated with docetaxel at a dose level of 100 to 115 mg/m2.In summary,docetaxel produced a sensorimotor peripheral neuropathy in 11%of our patient population. |
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adverse drug reaction
chemotherapy,CNS treatment and complications with
docetaxel
muscle pain
muscle weakness
nerve conduction studies
neuropathy
neuropathy,medication induced
neuropathy,peripheral
neuropathy,toxic
neurotoxic
polyneuropathy
weakness
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